If you have cancer, these protocols are in parallel to your cancer treatment

      The treatment plan for most pre-menopausal women and me is Tamoxifen. Even with Tamoxifen, my recurrance risk is 30% over 5 years. I find 30% frighteningly high. For me, Tamoxifen is not enough for me. I follow these treatments in order to mitigate as much risk as possible. I can not wait for the eventual larger studies that will be done on the SNPs that impair estrogen metabolism and IVF medications.

Diagnosis and Treatment Steps

1. Take the Estrogen Metabolism Gene Test 

2.  If you have SNPs on CYP1B1, CYP1A1, COMT or GSTM, take the Estrogen Metabolism and Methylation  Urine Test. 

3. Take Supplement to Improve Estrogen Pathways

4. Monitor the Efficacy of the Treatment through the Estrogen Urine Test

 

Estrogen Metabolism and Methylation Test

      Once it was determined that I had SNPs on CYP1B1, COMT and GSTM, I took an estrogen metabolizing and methylating urine test. This test showed that indeed, I was not excreting the toxic estrogens. The goal is to be able to both metabolize and methylate more effectively.

 

 

Babs' March 2009 Estrogen Ratios Babs' March 2009 Estrogen Ratios

As you can see here, while my metabolism of Estrogen is good, it the lack of Methylation which is creating risk. Increased Methylation is vital to decreasing recurrance risk.

 

TAMOXIFEN does not address these issues at all.

 

While my metabolism has improved even further, my methylation is not improving adequately, so the supplements I take have been increased.

Download
Babs' 3.2009 Estrogen Test Results
Babs' 3.2009 Estrogen Test Results.pdf
Adobe Acrobat document [3.8 MB]

Treatment for SNPs on CYP1B1, COMT, GSTM:

My initial treatment to compensate for the SNPs was: 

  • DHEA to decrease my CYP1B1 activity (2 SNPs)
  • DIM-PRO to increase my CYP1A1 activity
  • SAM-E to increase COMT response (2 SNPs)
  • NAC to increase GSTM (absent)

 

Download
Babs' Initial Treatment for DETOX SNPs
My SNP Treatment.pdf
Adobe Acrobat document [13.2 KB]
Download
Jen's Genomic Treatment for ER+ Breast Cancer
My friend Jen has ER+ Breast Cancer following years of Hormonal Replacement Therapy. Her diagnosis,treatment and ongoing monitoring is described.
Genomics Relative to ER+breast cancer.pd[...]
Adobe Acrobat document [90.2 KB]